Dielectricity of a molecularly crowded solution accelerates NTP misincorporation during RNA-dependent RNA polymerization by T7 RNA polymerase

Abstract In biological systems, the synthesis of nucleic acids, such as DNA and RNA, is catalyzed by enzymes in various US aqueous solutions.However, substrate specificity is derived from the chemical properties of the residues, which implies that perturbations of the solution environment may cause changes in the fidelity of the reaction.Here, we i

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Role of constitutive behavior and tumor-host mechanical interactions in the state of stress and growth of solid tumors.

Mechanical forces play a crucial role in tumor patho-physiology.Compression of cancer cells inhibits their proliferation rate, induces apoptosis and enhances their invasive and metastatic potential.Additionally, compression of intratumor blood vessels reduces the supply of oxygen, nutrients and AEG IKE84441FB MaxiSense 78cm Touch Control Four Zone

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